RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail.

X, Lin; G, Chai; Y, Wu; J, Li; F, Chen; J, Liu; G, Luo; J, Tauler; J, Du; S, Lin; C, He; H, Wang

doi:10.1038/s41467-019-09865-9

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RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail.

Shared by NobleBlocks on May 6, 2019 • 12:00 AM UTC

Authors:

Lin X

Chai G

Wu Y

Abstract

N6-Methyladenosine (m6A) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, m6A modification of mRNAs increases in cancer cells. Deletion of methyl...

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