Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus.

S, Rahman; D, Sagar; RN, Hanna; YL, Lightfoot; P, Mistry; CK, Smith; Z, Manna; S, Hasni; RM, Siegel; MA, Sanjuan; R, Kolbeck; MJ, Kaplan; KA, Casey

doi:10.1136/annrheumdis-2018-214620

Public

Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus.

Shared by NobleBlocks on Apr 30, 2019 • 12:00 AM UTC

Authors:

Rahman S

Sagar D

Hanna RN

Abstract

<h4>Objectives</h4>The presence of proinflammatory low-density granulocytes (LDG) has been demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) were identified in systemic lupus erythematosus (SLE). Becaus...

Subject

T cells

Autoimmune diseases

systemic lupus erythematosus

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