Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment

Lv, Ji; Jia, Yitao; Li, Jing; Kuai, Wentao; Li, Yang; Guo, Fang; Xu, Xinjian; Zhao, Zhaolong; Lv, Jian; Li, Zhongxin

doi:10.1038/s41419-019-1638-6

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Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment

Shared by NobleBlocks on May 28, 2019 • 12:00 AM UTC

Authors:

Ji Lv

Yitao Jia

Jing Li

Abstract

Abstract Therapeutic antibodies targeting PD-1 have made major breakthroughs in cancer treatment. However, the majority of colorectal cancer (CRC) cases are microsatellite stable (MSS) and do not respond to anti-PD-1-based immunotherapy. Combination therapy will be an ideal strategy to overcome this...

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