Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET.

R, Raavé; G, Sandker; P, Adumeau; CB, Jacobsen; F, Mangin; M, Meyer; M, Moreau; C, Bernhard; Costa L, Da; A, Dubois; V, Goncalves; M, Gustafsson; M, Rijpkema; O, Boerman; JC, Chambron; S, Heskamp; F, Denat

doi:10.1007/s00259-019-04343-2

Public

Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET.

Shared by NobleBlocks on Jun 3, 2019 • 12:00 AM UTC

Authors:

Raavé R

Sandker G

Adumeau P

Abstract

<h4>Purpose</h4>Currently, the most commonly used chelator for labelling antibodies with 89Zr for immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the limited in vivo stability of the 89Zr-DFO complex results in release of 89Zr, whic...

Subject

Monoclonal antibodies

89Zr

Dfo

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