Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.

MY, Li; XL, Zhu; BX, Zhao; L, Shi; W, Wang; W, Hu; SL, Qin; BH, Chen; PH, Zhou; B, Qiu; Y, Gao; BL, Liu

doi:10.1038/s41419-019-1728-5

Public

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.

Shared by NobleBlocks on Jun 20, 2019 • 12:00 AM UTC

Authors:

Li MY

Zhu XL

Zhao BX

Abstract

Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of ...

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