Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.

ZL, Ou; Z, Luo; Z, Luo; W, Wei; S, Liang; TL, Gao; YB, Lu

doi:10.1080/15476286.2019.1649585

Public

Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.

Shared by NobleBlocks on Aug 12, 2019 • 12:00 AM UTC

Authors:

Ou ZL

Luo Z

Abstract

One key to malignant progression of pancreatic cancer (PC) is the acquired ability of tumour cells to escape immune-mediated lysis. Hypoxic microenvironment plays a causal role in PC metastasis. According to previous studies, hypoxia could induce the upregulation of HIF1A, ADAM10 and sMICA, leading ...

Subject

Hypoxia

Immune escape

Mir-153

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