Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens.

X, Li; Q, Wang; L, Ding; YX, Wang; ZD, Zhao; N, Mao; CT, Wu; H, Wang; H, Zhu; SB, Ning

doi:10.1186/s13287-019-1384-9

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Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens.

Shared by NobleBlocks on Aug 23, 2019 • 12:00 AM UTC

Authors:

Li X

Wang Q

Ding L

Abstract

<h4>Background</h4>To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium.<h4>Methods</h4>Primary MSCs and ICAM-1-overexpressing MSCs (C3 cells) we...

Subject

Homing

Mesenchymal Stem Cells

Inflammatory Bowel Disease

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