Mutations in CHCHD2 cause α-synuclein aggregation.

A, Ikeda; K, Nishioka; H, Meng; M, Takanashi; I, Hasegawa; T, Inoshita; K, Shiba-Fukushima; Y, Li; H, Yoshino; A, Mori; A, Okuzumi; A, Yamaguchi; R, Nonaka; N, Izawa; KI, Ishikawa; H, Saiki; M, Morita; M, Hasegawa; K, Hasegawa; M, Elahi; M, Funayama; H, Okano; W, Akamatsu; Y, Imai; N, Hattori

doi:10.1093/hmg/ddz241

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Mutations in CHCHD2 cause α-synuclein aggregation.

Shared by NobleBlocks on Dec 1, 2019 • 12:00 AM UTC

Authors:

Ikeda A

Nishioka K

Meng H

Abstract

Mutations in CHCHD2 are linked to a familial, autosomal dominant form of Parkinson's disease (PD). The gene product may regulate mitochondrial respiratory function. However, whether mitochondrial dysfunction induced by CHCHD2 mutations further yields α-synuclein pathology is unclear. Here, we provid...

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