Application of the adverse outcome pathway framework to genotoxic modes of action.

JC, Sasaki; A, Allemang; SM, Bryce; L, Custer; KL, Dearfield; Y, Dietz; A, Elhajouji; PA, Escobar; AJ Jr, Fornace; R, Froetschl; S, Galloway; U, Hemmann; G, Hendriks; HH, Li; M, Luijten; G, Ouedraogo; L, Peel; S, Pfuhler; DJ, Roberts; V, Thybaud; Benthem J, van; CL, Yauk; M, Schuler

doi:10.1002/em.22339

Public

Application of the adverse outcome pathway framework to genotoxic modes of action.

Shared by NobleBlocks on Oct 31, 2019 • 12:00 AM UTC

Authors:

Sasaki JC

Allemang A

Bryce SM

Abstract

In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) framework. As AOPs are a relatively new approach in g...

Subject

Genotoxicity

Mode of action

Adverse Outcome Pathway

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