Homozygous mutations in <i>REC114</i> cause female infertility characterised by multiple pronuclei formation and early embryonic arrest

Wang, Wenjing; Dong, Jie; Chen, Biaobang; Du, Jing; Kuang, Yanping; Sun, Xiaoxi; Fu, Jing; Li, Bin; Mu, Jian; Zhang, Zhihua; Zhou, Zhou; Lin, Zhao; Wu, Ling; Yan, Zheng; Mao, Xiaoyan; Li, Qiaoli; He, Lin; Wang, Lei; Sang, Qing

doi:10.1136/jmedgenet-2019-106379

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Homozygous mutations in <i>REC114</i> cause female infertility characterised by multiple pronuclei formation and early embryonic arrest

Published in Journal of Medical Genetics • Nov 8, 2019

Authors:

Wenjing Wang

Jie Dong

Biaobang Chen

Abstract

Background Abnormal pronuclear formation during fertilisation and subsequent early embryonic arrest results in female infertility. In recent years, with the prevalence of assisted reproductive technology, a few genes have been identified that are involved in female infertility caused by abnormalitie...

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