Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-genome wide association study

Nalls, M.; Blauwendraat, C.; Vallerga, C.; Heilbron, K.; Bandres-Ciga, S.; Chang, Diana; Tan, M.; Kia, D.; Noyce, A.; Xue, Angli; Bras, J.; Young, Emily; Coelln, R.; Simón-Sánchez, J.; Schulte, C.; Sharma, Manu; Krohn, L.; Pihlstrøm, L.; Siitonen, A.; Iwaki, H.; Leonard, H.; Faghri, F.; R. Gibbs, J.; Hernandez, D.; W. Scholz, Sonja; Botía, J.; Martinez, Maria; Corvol, J.; Lesage, S.; Jankovic, J.; Shulman, L.; Sutherland, Margaret; Tienari, P.; Majamaa, K.; Toft, M.; Andreassen, O.; Bangale, Tushar; Brice, A.; Yang, Jian; Gan-Or, Z.; Gasser, T.; Heutink, P.; Shulman, J.; Wood, N.; Hinds, D.; Hardy, J.; Morris, H.; Gratten, J.; Visscher, P.; Graham, R.; Singleton, A.; Adarmes-Gómez, A.; Aguilar, M.; Aitkulova, A.; Akhmetzhanov, Vadim; Alcalay, R.; Álvarez, I.; Álvarez, V.; Barrero, F.; A. B. Yarza, J.; Bernal‐Bernal, I.; J. Billingsley, Kimberley; Blázquez, M.; Bonilla‐Toribio, Marta; Botía, J.; Boungiorno, M.; Brockmann, K.; Bubb, V.; Buiza‐Rueda, D.; Cámara, A.; Carrillo, F.; Carrión-Claro, M.; Cerdán, D.; Chelban, V.; Clarimón, J.; Clarke, C.; Compta, Y.; Cookson, M.; Craig, D.; Danjou, F.; Diez-Fairen, M.; Dols-Icardo, O.; Duarte, J.; Durán, R.; Escamilla-Sevilla, F.; Escott-Price, V.; Ezquerra, M.; Feliz, C.; Fernández, M.; Fernández-Santiago, R.; Finkbeiner, S.; Foltynie, T.; García, C.; Garcia-Ruiz, P.; G. Heredia, M.; Gómez-Garre, P.; González, M.; González‐Aramburu, I.; Guelfi, S.; Guerreiro, R.; Hardy, J.; Hassin-Baer, S.; Hoenicka, J.; Holmans, P.; Houlden, H.; Infante, J.; Jesús, S.; Jiménez-Escrig, A.; Kaishybayeva, Gulnaz; Kaiyrzhanov, R.; Karimova, A.; J. Kinghorn, K.; Kõks, S.; Kulisevsky, J.; Labrador-Espinosa, M.; Leonard, H.; Lewis, P.; López-Sendón, J.; Lovering, R.; Lubbe, S.; Lungu, C.; Macias, D.; Manzoni, C.; Marín, J.; Marinus, J.; Marti, M.; M. Torres, I.; Martínez-Castrillo, J.; Mata, M.; Mencacci, N.; Méndez-del-Barrio, C.; Middlehurst, B.; Mínguez, A.; Mir, P.; Mok, K.; Muñoz, E.; P. Narendra, Derek; Ojo, O.; Okubadejo, N.; Pagola, A.; Pastor, P.; Errazquin, F.; Periñán-Tocino, T.; Pihlstrøm, L.; Plun-Favreau, H.; Quinn, J.; R'bibo, L.; Reed, X.; Rezola, E.; Rizig, M.; Rizzu, P.; Robak, L.; Rodríguez, A.; Rouleau, G.; Ruiz‐Martinez, J.; Ruz, C.; Ryten, M.; Sadykova, D.; Schreglmann, S.; Shashkin, C.; Sierra, M.; Suárez-Sanmartin, E.; Taba, P.; Tabernero, C.; Tan, Manuela; Tartari, J.; Tejera-Parrado, C.; Tolosa, E.; Trabzuni, D.; Valldeoriola, F.; J. Hilten, J.; Keuren-Jensen, K.; Vargas‐González, L.; Vela, L.; Vives, F.; Williams, N.; Zharkinbekova, N.; Zharmukhanov, Zharkyn; Zholdybayeva, Elena; Zimprich, A.; Ylikotila, P.; Shulman, L.; Reich, S.; Savitt, J.; Agee, M.; Alipanahi, B.; Auton, A.; Bell, R.; Bryc, K.; Elson, S.; Fontanillas, P.; Furlotte, N.; Huber, K.; Hicks, B.; Jewett, E.; Jiang, Yunxuan; Kleinman, A.; Lin, Keng-Han; Litterman, N.; McCreight, J.; McIntyre, M.; McManus, K.; Mountain, J.; Noblin, E.; Northover, C.; Pitts, S.; D. Poznik, G.; Sathirapongsasuti, J.; Shelton, J.; Shringarpure, S.; Tian, C.; Tung, J.; Vacic, V.; Wang, Xin; Wilson, C.; Anderson, Tim; R. Bentley, Steven; Dalrymple-Alford, J.; Fowdar, Javed; Halliday, G.; Henders, A.; Hickie, I.; Kassam, I.; Kennedy, Martin; W Kwok, John; Lewis, S.; Mellick, G.; M Montgomery, Grant; Pearson, J.; L. Pitcher, Toni; Sidorenko, J.; Silburn, P.; Vallerga, C.; Visscher, P.; Wallace, L.; Wray, N.; Zhang, Futao

doi:10.1016/S1474-4422(19)30320-5

Public

Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-genome wide association study

Published in The Lancet. Neurology • Dec 1, 2019

Authors:

M. Nalls

C. Blauwendraat

C. Vallerga

Abstract

SUMMARY Background Genome-wide association studies (GWASs) in Parkinson’s disease (PD) have increased the scope of biological knowledge about the disease over the past decade. We sought to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into disease etiolo...

Subject

Biology

Medicine

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