Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

Z, Wang; VH, Wu; MM, Allevato; M, Gilardi; Y, He; Callejas-Valera J, Luis; L, Vitale-Cross; D, Martin; P, Amornphimoltham; J, Mcdermott; BS, Yung; Y, Goto; AA, Molinolo; AB, Sharabi; EEW, Cohen; Q, Chen; JG, Lyons; LB, Alexandrov; JS, Gutkind

doi:10.1038/s41467-019-13471-0

Public

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

Shared by NobleBlocks on Dec 5, 2019 • 12:00 AM UTC

Authors:

Wang Z

Wu VH

Allevato MM

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited acti...

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