HIF-2α regulates CD44 to promote cancer stem cell activation in triple-negative breast cancer <i>via</i> PI3K/AKT/mTOR signaling.

J, Bai; WB, Chen; XY, Zhang; XN, Kang; LJ, Jin; H, Zhang; ZY, Wang

doi:10.4252/wjsc.v12.i1.87

Public

HIF-2α regulates CD44 to promote cancer stem cell activation in triple-negative breast cancer <i>via</i> PI3K/AKT/mTOR signaling.

Shared by NobleBlocks on Jan 1, 2020 • 12:00 AM UTC

Authors:

Bai J

Chen WB

Zhang XY

Abstract

<h4>Background</h4>Breast cancer is a common malignant tumor that seriously threatens women's health. Breast cancer stem cell (CSC)-like cell population may be the main factor for breast cancer metastasis. Therefore, targeted therapy for CSCs has great potential significance. Hypoxia-inducible facto...

Subject

Breast cancer

CD44

Cancer Stem Cells

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