Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

F, Watanabe; K, Suzuki; S, Tamaki; I, Abe; Y, Endo; Y, Takayama; H, Ishikawa; N, Kakizawa; M, Saito; K, Futsuhara; H, Noda; F, Konishi; T, Rikiyama

doi:10.1371/journal.pone.0227366

Public

Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

Shared by NobleBlocks on Dec 31, 2019 • 12:00 AM UTC

Authors:

Watanabe F

Suzuki K

Tamaki S

Abstract

<h4>Background</h4>Liquid biopsies enable the detection of circulating tumor DNA (ctDNA). However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential.<h4>Methods and findings</h4>A total of 422 blood sam...

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