Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.

K, Hu; K, Li; J, Lv; J, Feng; J, Chen; H, Wu; F, Cheng; W, Jiang; J, Wang; H, Pei; PJ, Chiao; Z, Cai; Y, Chen; M, Liu; X, Pang

doi:10.1172/jci124049

Public

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.

Shared by NobleBlocks on Apr 1, 2020 • 12:00 AM UTC

Authors:

Hu K

Li K

Lv J

Abstract

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin...

Subject

Cancer

Drug therapy

Oncology

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