Control of protein function through oxidation and reduction of persulfidated states.

É, Dóka; T, Ida; M, Dagnell; Y, Abiko; NC, Luong; N, Balog; T, Takata; B, Espinosa; A, Nishimura; Q, Cheng; Y, Funato; H, Miki; JM, Fukuto; JR, Prigge; EE, Schmidt; ESJ, Arnér; Y, Kumagai; T, Akaike; P, Nagy

doi:10.1126/sciadv.aax8358

Public

Control of protein function through oxidation and reduction of persulfidated states.

Shared by NobleBlocks on Jan 1, 2020 • 12:00 AM UTC

Authors:

Dóka É

Ida T

Dagnell M

Abstract

Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein function. We found that persulfidation (CysSSH) protects Cys from irreversible oxidative loss of function by the formation of CysSSO<sub>1-3</sub>H derivatives that can subsequently be reduced back to native ...

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