Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

Y, Liu; Y, Fang; X, Chen; Z, Wang; X, Liang; T, Zhang; M, Liu; N, Zhou; J, Lv; K, Tang; J, Xie; Y, Gao; F, Cheng; Y, Zhou; Z, Zhang; Y, Hu; X, Zhang; Q, Gao; Y, Zhang; B, Huang

doi:10.1126/sciimmunol.aax7969

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Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

Shared by NobleBlocks on Jan 1, 2020 • 12:00 AM UTC

Authors:

Liu Y

Fang Y

Chen X

Abstract

Cytokine release syndrome (CRS) counteracts the effectiveness of chimeric antigen receptor (CAR) T cell therapy in cancer patients, but the mechanism underlying CRS remains unclear. Here, we show that tumor cell pyroptosis triggers CRS during CAR T cell therapy. We find that CAR T cells rapidly acti...

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