Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.

JF, Teng; QB, Mei; XG, Zhou; Y, Tang; R, Xiong; WQ, Qiu; R, Pan; BY, Law; VK, Wong; CL, Yu; HA, Long; XL, Xiao; F, Zhang; JM, Wu; DL, Qin; AG, Wu

doi:10.3390/cancers12010193

Public

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer.

Shared by NobleBlocks on Jan 13, 2020 • 12:00 AM UTC

Authors:

Teng JF

Mei QB

Zhou XG

Abstract

<i>Trillium tschonoskii</i> Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation of non-small cell lung cancer (NSCLC) v...

Subject

NSCLC

Pyroptosis

Polyphyllin Vi

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