Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition.

W, Jin

doi:10.3390/cells9010217

Public

Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition.

Shared by NobleBlocks on Jan 15, 2020 • 12:00 AM UTC

Authors:

Jin W

Abstract

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers. Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition of cancer stem cells (CSCs), and chemoresistance in cancer via enhancing the epithelial-mesenchymal transition (EMT). ...

Subject

Metastasis

Jak/stat

Epithelial–mesenchymal Transition (Emt)

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