The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

Thanh Hoang Thi, Thai; H. Pilkington, Emily; Hai Nguyen, Dai; Seok Lee, Jung; Dong Park, Ki; P. Truong, Nghia

doi:10.3390/polym12020298

Public

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

Shared by NobleBlocks on Feb 2, 2020 • 12:00 AM UTC

Authors:

Thai Thanh Hoang Thi

Emily H. Pilkington

Dai Hai Nguyen

Abstract

Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles is a w...

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