Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Walsh, M.; Merkel, P.; Peh, C.; Szpirt, W.; Puéchal, X.; Fujimoto, S.; Hawley, C.; Khalidi, N.; Flossmann, O.; Wald, R.; Girard, L.; Levin, A.; Gregorini, G.; Harper, L.; Clark, W.; Pagnoux, C.; Specks, U.; Smyth, L.; Tesar, V.; Ito-Ihara, T.; D. de Zoysa, J.; Szczeklik, W.; Flores-Suárez, L.; Carette, S.; Guillevin, L.; Pusey, C.; Casian, A.; Brezina, B.; Mazzetti, Andrea; A. McAlear, Carol; Broadhurst, E.; Reidlinger, DM; Mehta, S.; Ives, N.; Jayne, D.

doi:10.1056/NEJMoa1803537

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Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Shared by NobleBlocks on Feb 12, 2020 • 12:00 AM UTC

Authors:

M. Walsh

P. Merkel

C. Peh

Abstract

BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with seve...

Subject

Medicine

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