Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project.

DM, Merino; LM, McShane; D, Fabrizio; V, Funari; SJ, Chen; JR, White; P, Wenz; J, Baden; JC, Barrett; R, Chaudhary; L, Chen; WS, Chen; JH, Cheng; D, Cyanam; JS, Dickey; V, Gupta; M, Hellmann; E, Helman; Y, Li; J, Maas; A, Papin; R, Patidar; KJ, Quinn; N, Rizvi; H, Tae; C, Ward; M, Xie; A, Zehir; C, Zhao; M, Dietel; A, Stenzinger; M, Stewart; J, Allen

doi:10.1136/jitc-2019-000147

Public

Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project.

Shared by NobleBlocks on Mar 1, 2020 • 12:00 AM UTC

Authors:

Merino DM

McShane LM

Fabrizio D

Abstract

<h4>Background</h4>Tumor mutational burden (TMB), defined as the number of somatic mutations per megabase of interrogated genomic sequence, demonstrates predictive biomarker potential for the identification of patients with cancer most likely to respond to immune checkpoint inhibitors. TMB is optima...

Subject

TMB

Biomarker

Harmonization

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