Semaglutide lowers body weight in rodents via distributed neural pathways.

S, Gabery; CG, Salinas; SJ, Paulsen; J, Ahnfelt-Rønne; T, Alanentalo; AF, Baquero; ST, Buckley; E, Farkas; C, Fekete; KS, Frederiksen; HCC, Helms; JF, Jeppesen; LM, John; C, Pyke; J, Nøhr; TT, Lu; J, Polex-Wolf; V, Prevot; K, Raun; L, Simonsen; G, Sun; A, Szilvásy-Szabó; H, Willenbrock; A, Secher; LB, Knudsen; WFJ, Hogendorf

doi:10.1172/jci.insight.133429

Public

Semaglutide lowers body weight in rodents via distributed neural pathways.

Shared by NobleBlocks on Mar 26, 2020 • 12:00 AM UTC

Authors:

Gabery S

Salinas CG

Paulsen SJ

Abstract

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here sh...

Subject

Metabolism

Obesity

Neuroscience

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