Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance.

KHM, Roumans; L, Lindeboom; P, Veeraiah; CME, Remie; E, Phielix; B, Havekes; YMH, Bruls; MCGJ, Brouwers; M, Ståhlman; M, Alssema; HPF, Peters; Mutsert R, de; B, Staels; MR, Taskinen; J, Borén; P, Schrauwen; VB, Schrauwen-Hinderling

doi:10.1038/s41467-020-15684-0

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Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance.

Shared by NobleBlocks on Apr 20, 2020 • 12:00 AM UTC

Authors:

Roumans KHM

Lindeboom L

Veeraiah P

Abstract

Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resista...

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