Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers.

H, Qiu; B, Shuai; YZ, Wang; D, Liu; YG, Chen; PS, Gao; HX, Ma; S, Chen; TS, Mei

doi:10.1021/jacs.9b13117

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Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers.

Shared by NobleBlocks on May 21, 2020 • 12:00 AM UTC

Authors:

Qiu H

Shuai B

Wang YZ

Abstract

A scalable enantioselective nickel-catalyzed electrochemical reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell. Common metal reductants such as Mn or Z...

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