Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation.

T, Ali; SU, Rahman; Q, Hao; W, Li; Z, Liu; Shah F, Ali; I, Murtaza; Z, Zhang; X, Yang; G, Liu; S, Li

doi:10.1111/jpi.12667

Public

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation.

Shared by NobleBlocks on Jul 17, 2020 • 12:00 AM UTC

Authors:

Ali T

Rahman SU

Hao Q

Abstract

Major depressive disorder (MDD) is a life-threatening illness characterized by mood changes and high rates of suicide. Although the role of neuroinflammation in MMD has been studied, the mechanistic interplay between antidepressants, neuroinflammation, and autophagy is yet to be investigated. The pr...

Subject

Melatonin

Lipopolysaccharides

Depression

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