Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate

Krishna Nimmagadda, Sri; Korapati, Satish; Dasgupta, Debottam; Abdul Malik, Noormohamed; Vinodini, Arun; S. Gangu, Aravind; Srinivas, K.; Maity, Prantik; Sankar Bondigela, Siva; Venu, Alla; P. Gallagher, William; Aytar, Selin; González‐Bobes, Francisco; Vaidyanathan, Rajappa

doi:10.1021/acs.oprd.0c00134

Public

Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate

Shared by NobleBlocks on May 18, 2020 • 12:00 AM UTC

Authors:

Sri Krishna Nimmagadda

Satish Korapati

Debottam Dasgupta

Abstract

We describe the development and scale-up of a nickel-catalyzed reductive cross-electrophile coupling reaction between a substituted 2-chloropyridine and ethyl 3-chloropropanoate using manganese dust as the terminal reductant. Several additives were screened for the activation of the manganese reduct...

Subject

Manganese

Catalysis

Yield (engineering)

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!