Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent.

A, Mazzoni; L, Salvati; L, Maggi; M, Capone; A, Vanni; M, Spinicci; J, Mencarini; R, Caporale; B, Peruzzi; A, Antonelli; M, Trotta; L, Zammarchi; L, Ciani; L, Gori; C, Lazzeri; A, Matucci; A, Vultaggio; O, Rossi; F, Almerigogna; P, Parronchi; P, Fontanari; F, Lavorini; A, Peris; GM, Rossolini; A, Bartoloni; S, Romagnani; F, Liotta; F, Annunziato; L, Cosmi

doi:10.1172/jci138554

Public

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent.

Shared by NobleBlocks on Sep 1, 2020 • 12:00 AM UTC

Authors:

Mazzoni A

Salvati L

Maggi L

Abstract

BACKGROUNDCoronavirus disease 19 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen clearance; however, in some patients an excessive and aberrant host immune response can lead to an acute respiratory distress syndrome. The com...

Subject

Cytokines

Infectious disease

NK cells

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