The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure.

R, Barquera; DI, Hernández-Zaragoza; A, Bravo-Acevedo; E, Arrieta-Bolaños; S, Clayton; V, Acuña-Alonzo; JC, Martínez-Álvarez; C, López-Gil; C, Adalid-Sáinz; MDR, Vega-Martínez; A, Escobedo-Ruíz; ED, Juárez-Cortés; A, Immel; H, Pacheco-Ubaldo; L, González-Medina; A, Lona-Sánchez; J, Lara-Riegos; MGJ, Sánchez-Fernández; R, Díaz-López; GU, Guizar-López; CE, Medina-Escobedo; MA, Arrazola-García; GD, Montiel-Hernández; O, Hernández-Hernández; la Cruz FDR, Ramos-de; F, Juárez-Nicolás; JA, Pantoja-Torres; TJ, Rodríguez-Munguía; V, Juárez-Barreto; H, Delgado-Aguirre; AB, Escutia-González; I, Goné-Vázquez; G, Benítez-Arvizu; FP, Arellano-Prado; VE, García-Arias; ME, Rodríguez-López; P, Méndez-Mani; R, García-Álvarez; MDR, González-Martínez; G, Aquino-Rubio; N, Escareño-Montiel; TV, Vázquez-Castillo; MG, Uribe-Duarte; MJ, Ruíz-Corral; A, Ortega-Yáñez; N, Bernal-Felipe; B, Gómez-Navarro; AJ, Arriaga-Perea; V, Martínez-Bezies; RM, Macías-Medrano; JA, Aguilar-Campos; R, Solís-Martínez; R, Serrano-Osuna; MJ, Sandoval-Sandoval; Y, Jaramillo-Rodríguez; A, Salgado-Adame; la Cruz F, Juárez-de; B, Novelo-Garza; MLÁ, Pavón-Vargas; N, Salgado-Galicia; MC, Bortolini; C, Gallo; G, Bedoya; F, Rothhammer; R, González-José; A, Ruiz-Linares; S, Canizales-Quinteros; S, Romero-Hidalgo; J, Krause; J, Zúñiga; EJ, Yunis; C, Bekker-Méndez; J, Granados

doi:10.1016/j.humimm.2020.06.008

Public

The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure.

Shared by NobleBlocks on Jul 8, 2020 • 12:00 AM UTC

Authors:

Barquera R

Hernández-Zaragoza DI

Bravo-Acevedo A

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and thei...

Subject

Population genetics

HLA

Admixture

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