Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Hadjadj, J.; Yatim, N.; Barnabei, L.; Corneau, A.; Boussier, J.; Smith, Nikaïa; Péré, H.; Charbit, B.; Bondet, V.; Chenevier-Gobeaux, C.; Breillat, P.; Carlier, Nicolas; Gauzit, R.; Morbieu, C.; Pène, F.; Marin, N.; Roche, N.; Szwebel, T.; Merkling, S.; Treluyer, J.; Veyer, D.; Mouthon, L.; Blanc, C.; Tharaux, P.; Rozenberg, F.; Fischer, A.; Duffy, D.; Rieux-Laucat, F.; Kernéis, S.; Terrier, B.

doi:10.1126/science.abc6027

Public

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Shared by NobleBlocks on Jul 13, 2020 • 12:00 AM UTC

Authors:

J. Hadjadj

N. Yatim

L. Barnabei

Abstract

Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions. Type I IFNs (IFN-α and IFN-β) are widely expres...

Subject

Medicine

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