LncRNA GATA3-AS1 facilitates tumour progression and immune escape in triple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1.

M, Zhang; N, Wang; P, Song; Y, Fu; Y, Ren; Z, Li; J, Wang

doi:10.1111/cpr.12855

Public

LncRNA GATA3-AS1 facilitates tumour progression and immune escape in triple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1.

Shared by NobleBlocks on Jul 20, 2020 • 12:00 AM UTC

Authors:

Zhang M

Wang N

Song P

Abstract

<h4>Objectives</h4>Long non-coding RNAs (lncRNAs) have been demonstrated as crucial regulators in cancer, but whether they are involved in the immune response of cancer cells remains largely undiscovered. GATA3-AS1 is a novel lncRNA that was upregulated in breast cancer (BC) according to online data...

Subject

Immune escape

PD-L1

Triple-negative Breast Cancer

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