Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.

IF, Harrison; O, Ismail; A, Machhada; N, Colgan; Y, Ohene; P, Nahavandi; Z, Ahmed; A, Fisher; S, Meftah; TK, Murray; OP, Ottersen; EA, Nagelhus; MJ, O'Neill; JA, Wells; MF, Lythgoe

doi:10.1093/brain/awaa179

Public

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.

Shared by NobleBlocks on Aug 1, 2020 • 12:00 AM UTC

Authors:

Harrison IF

Ismail O

Machhada A

Abstract

The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer's disease. Further, tau protein transference via the extracellular sp...

Subject

Tau

Alzheimer’s disease

aquaporin-4

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