Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

Knight, S.; Ho, A.; Pius, R.; E. Buchan, Iain; Carson, G.; Drake, T.; Dunning, J.; Fairfield, C.; Gamble, C.; A. Green, C.; K. Gupta, Rishi; Halpin, S.; Hardwick, H.; Holden, K.; Horby, P.; Jackson, C.; McLean, K.; Merson, L.; Nguyen-Van-Tam, J.; Norman, Lisa; Noursadeghi, M.; Olliaro, P.; Pritchard, M.; Russell, C.; A Shaw, Catherine; Sheikh, Aziz; Solomon, Tommy; Sudlow, C.; Swann, O.; Turtle, L.; Openshaw, P.; Baillie, J.; Semple, M.; Docherty, A.; Harrison, E.; Baillie, J.; Semple, M.; Openshaw, P.; Carson, G.; Alex, Beatrice; Bach, Benjamin; Barclay, W.; Bogaert, D.; Chand, M.; S. Cooke, Graham; Docherty, A.; Dunning, J.; da Silva Filipe, A.; Fletcher, T.; A. Green, C.; Harrison, E.; Hiscox, J.; Ho, A.; Horby, P.; Ijaz, S.; Khoo, S.; Klenerman, P.; Law, Andrew; Lim, W.; Mentzer, A.; Merson, L.; Meynert, A.; Noursadeghi, M.; Moore, S.; Palmarini, M.; Paxton, W.; Pollakis, G.; . C. Price, NicholasS; Rambaut, A.; L. Robertson, David; Russell, C.; Sancho-Shimizu, V.; Scott, J.; Sigfrid, L.; Solomon, Tommy; Sriskandan, S.; Stuart, D.; Summers, C.; Tedder, R.; Thomson, E.; Thwaites, R.; Turtle, L.; Zambon, M.; Hardwick, H.; Donohue, C.; Ewins, Jane; Oosthuyzen, W.; Griffiths, Fiona; Norman, Lisa; Pius, R.; M. Drake, Tom; Fairfield, C.; Knight, S.; McLean, K.; Murphy, D.; A Shaw, Catherine; Dalton, J.; Girvan, M.; Savičiūtė, Eglė; Roberts, S.; R Harrison, Janet; Marsh, Laura; Connor, M.; Halpin, S.; Jackson, C.; Gamble, C.; Leeming, G.; Hendry, Ross; Scott-Brown, J.; Greenhalf, W.; Shaw, V.; E. McDonald, Sarah; Ahmed, K.; Armstrong, J.; Ashworth, M.; G. Asiimwe, I.; Bakshi, Siddharth; Barlow, S.; J. Booth, Laura; Brennan, B.; Bullock, K.; W. A. Catterall, Benjamin; Clark, J.; Clarke, Emily; J. Cole, Sarah; Cooper, L.; Cox, H.; Davis, Christopher; Dincarslan, Oslem; Dunn, Chris; Dyer, P.; Elliott, A.; Evans, A.; W S Fisher, Lewis; Foster, T.; García-Dorival, Isabel; Greenhalf, W.; Gunning, P.; S. Hartley, Catherine; Ho, A.; Jensen, R.; Jones, Christopher; Jones, T.; Khandaker, Shadia; King, K.; T Kiy, Robyn; Koukorava, Chrysa; Lake, Annette; Lant, S.; Latawiec, D.; Lavelle-Langham, L.; Lefteri, Daniella; Lett, Lauren; A. Livoti, Lucia; Mancini, Maria; McEvoy, L.; Mclauchlan, J.; Metelmann, S.; Miah, Nahida; Middleton, J.; Mitchell, J.; Murphy, E.; Penrice-Randal, R.; Pilgrim, J.; Prince, T.; Reynolds, W.; Ridley, P.; Sales, Debby; Shaw, V.; Shears, R.; Small, B.; S Subramaniam, Krishanthi; Szemiel, Agnieska; Taggart, Aislynn; Tanianis-Hughes, Jolanta; Thomas, Jordan; Trochu, E.; van Tonder, Libby; Wilcock, Eve; Zhang, J.; Adeniji, K.; Agranoff, D.; Agwuh, K.; Ail, D.; Alegria, A.; Angus, Brian; Ashish, A.; Atkinson, Doug; Bari, S.; Barlow, G.; Barnass, S.; A. Barrett, Nicholas; Bassford, C.; Baxter, D.; Beadsworth, M.; Bernatoniene, J.; Berridge, J.; Best, N.; Bothma, P.; Brealey, D.; Brittain-Long, R.; Bulteel, N.; G Burden, Thomas; Burtenshaw, A.; Caruth, Vikki; Chadwick, D.; Chambler, D.; Chee, Nigel; Child, J.; Chukkambotla, S.; Clark, Tom; Collini, P.; Cosgrove, C.; Cupitt, J.; Cutino-Moguel, Maria-Teresa; Dark, P.; Dawson, Chris; Dervisevic, S.; Donnison, P.; Douthwaite, S.; DuRand, I.; Dushianthan, A.; Dyer, Tristan; Evans, C.; Eziefula, C.; Fegan, C.; Finn, A.; Fullerton, D.; Garg, S.; Garg, A.; Godden, J.; Goldsmith, A.; Graham, Clive; Hardy, E.; Hartshorn, S.; Harvey, D.; Havalda, P.; Hawcutt, D.; Hobrok, M.; Hodgson, L.; Holme, Anita; Hormis, A.; Jacobs, M.; Jain, Susan; Jennings, P.; Kaliappan, A.; Kasipandian, V.; Kegg, S.; R. Kelsey, Michael; Kendall, J.; Kerrison, C.; Kerslake, I.; Koch, O.; Koduri, G.; Koshy, G.; Laha, S.; G. Larkin, Susan; Leiner, T.; Lillie, P.; Limb, James; Linnett, V.; Little, J.; MacMahon, M.; Macnaughton, E.; Mankregod, Ravish; Masson, Huw; Matovu, E.; McCullough, K.; Mcewen, R.; Meda, M.; Mills, G.; Minton, J.; Mirfenderesky, M.; Mohandas, K.; Mok, Quen; Moon, J.; Moore, Elinoor; Morgan, P.; Morris, C.; Mortimore, K.; Moses, S.; A Mpenge, Mbiye; Mulla, Rohinton; J. Murphy, Michael; L. Nagel, Megan; Nagarajan, T.; Nelson, M.; Otahal, I.; Pais, M.; Panchatsharam, S.; Paraiso, Hassan; Patel, B.; Pepperell, J.; Peters, M.; Phull, M.; Pintus, S.; Pooni, J.; Post, F.; Price, D.; Prout, R.; Rae, N.; Reschreiter, H.; Reynolds, Tim; Richardson, Neil; Roberts, M.; Roberts, D.; Rose, A.; Rousseau, G.; J. Ryan, Brendan; Saluja, Taranprit; Shah, A.; Shanmuga, Prad; Sharma, Anil; Shawcross, A.; Sizer, J.; Smith, Richard; Snelson, C.; Spittle, N.; Staines, N.; Stambach, T.; Stewart, R.; Subudhi, P.; Szakmany, T.; Tatham, K.; Thomas, Jordan; Thompson, C.; Thompson, R.; Tridente, A.; Tupper-Carey, D.; Twagira, M.; Ustianowski, A.; Vallotton, N.; Vincent-Smith, L.; Visuvanathan, S.; Vuylsteke, A.; Waddy, S.; Wake, R.; Walden, A.; Welters, I.; Whitehouse, T.; Whittaker, P.; Whittington, A.; Wijesinghe, M.; Williams, Martin; Wilson, Lawrence; Wilson, S.; Winchester, S.; Wiselka, M.; Wolverson, A.; Wooton, D.; Workman, A.; Yates, B.; Young, Peter

doi:10.1136/bmj.m3339

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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

Shared by NobleBlocks on Aug 2, 2020 • 12:00 AM UTC

Authors:

S. Knight

A. Ho

R. Pius

Abstract

Abstract Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational cohort study. Setting International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) ...

Subject

Medicine

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