Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling.

W, Huang; Y, Man; C, Gao; L, Zhou; J, Gu; H, Xu; Q, Wan; Y, Long; L, Chai; Y, Xu; Y, Xu

doi:10.1155/2020/4074832

Public

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling.

Shared by NobleBlocks on Aug 1, 2020 • 12:00 AM UTC

Authors:

Huang W

Man Y

Gao C

Abstract

Diabetic nephropathy (DN) is a chronic low-grade inflammatory disease. Oxidative stress and nuclear factor kappa B (NF-κB) signaling play an important role in the pathogenesis of DN. Short-chain fatty acids (SCFAs) produced from carbohydrate fermentation in the gastrointestinal tract exert po...

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