Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses.

S, Schandelmaier; M, Briel; R, Varadhan; CH, Schmid; N, Devasenapathy; RA, Hayward; J, Gagnier; M, Borenstein; der Heijden GJMG, van; IJ, Dahabreh; X, Sun; W, Sauerbrei; M, Walsh; JPA, Ioannidis; L, Thabane; GH, Guyatt

doi:10.1503/cmaj.200077

Public

Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses.

Shared by NobleBlocks on Aug 1, 2020 • 12:00 AM UTC

Authors:

Schandelmaier S

Briel M

Varadhan R

Abstract

<h4>Background</h4>Most randomized controlled trials (RCTs) and meta-analyses of RCTs examine effect modification (also called a subgroup effect or interaction), in which the effect of an intervention varies by another variable (e.g., age or disease severity). Assessing the credibility of an apparen...

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