Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.

P, Skendros; A, Mitsios; A, Chrysanthopoulou; DC, Mastellos; S, Metallidis; P, Rafailidis; M, Ntinopoulou; E, Sertaridou; V, Tsironidou; C, Tsigalou; M, Tektonidou; T, Konstantinidis; C, Papagoras; I, Mitroulis; G, Germanidis; JD, Lambris; K, Ritis

doi:10.1172/jci141374

Public

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.

Shared by NobleBlocks on Nov 1, 2020 • 12:00 AM UTC

Authors:

Skendros P

Mitsios A

Chrysanthopoulou A

Abstract

Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how complement interacts with the platelet/neutrophil extr...

Subject

Complement

Neutrophils

Thrombosis

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