GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.

Q, Wu; W, Ba-Alawi; G, Deblois; J, Cruickshank; S, Duan; E, Lima-Fernandes; J, Haight; SAM, Tonekaboni; AM, Fortier; H, Kuasne; TD, McKee; H, Mahmoud; M, Kushida; S, Cameron; N, Dogan-Artun; W, Chen; Y, Nie; LX, Zhang; RN, Vellanki; S, Zhou; P, Prinos; BG, Wouters; PB, Dirks; SJ, Done; M, Park; DW, Cescon; B, Haibe-Kains; M, Lupien; CH, Arrowsmith

doi:10.1038/s41467-020-18020-8

Public

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.

Shared by NobleBlocks on Aug 21, 2020 • 12:00 AM UTC

Authors:

Wu Q

Ba-Alawi W

Deblois G

Abstract

Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter 1 (GLUT1, encoded by S...

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