Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

Suk Lee, Won; Yang, Hannah; Jae Chon, Hong; Kim, Chan

doi:10.1038/s12276-020-00500-y

Public

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

Shared by NobleBlocks on Sep 1, 2020 • 12:00 AM UTC

Authors:

Won Suk Lee

Hannah Yang

Hong Jae Chon

Abstract

Abstract Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a formidable barrier that severely impairs the efficacy of ICIs. While the crosstalk between tumor vessels and immune ce...

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