DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity.

DC, Turner; PP, Gorski; MF, Maasar; RA, Seaborne; P, Baumert; AD, Brown; MO, Kitchen; RM, Erskine; I, Dos-Remedios; S, Voisin; N, Eynon; RI, Sultanov; OV, Borisov; AK, Larin; EA, Semenova; DV, Popov; EV, Generozov; CE, Stewart; B, Drust; DJ, Owens; II, Ahmetov; AP, Sharples

doi:10.1038/s41598-020-72730-z

Public

DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity.

Shared by NobleBlocks on Sep 21, 2020 • 12:00 AM UTC

Authors:

Turner DC

Gorski PP

Maasar MF

Abstract

Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue have not been undertaken. Using 850K DNA methylation arrays we compared the ...

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