Phylogenomic analyses of the <i>Staphylococcaceae</i> family suggest the reclassification of five species within the genus <i>Staphylococcus</i> as heterotypic synonyms, the promotion of five subspecies to novel species, the taxonomic reassignment of five <i>Staphylococcus</i> species to <i>Mammaliicoccus</i> gen. nov., and the formal assignment of <i>Nosocomiicoccus</i> to the family <i>Staphylococcaceae</i>.