Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice.

J, Xu; X, Wang; J, Chen; S, Chen; Z, Li; H, Liu; Y, Bai; F, Zhi

doi:10.7150/thno.47683

Public

Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice.

Shared by NobleBlocks on Oct 30, 2020 • 12:00 AM UTC

Authors:

Xu J

Wang X

Chen J

Abstract

<b>Rationale:</b> Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD) due to their immunomodulatory and trophic functions. However, their efficacy is influenced by tissue origin, donator condition, isolation, and expansion methods. Here, we...

Subject

Mesenchymal stem cell

Insulin-like growth factor-1

Inflammatory Bowel Disease

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