Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived<i>NRXN1</i>-Mutant Neurons

<h4>ABSTRACT</h4> Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation predisposing to schizophrenia. Previous studies showed that engineered heterozygous NRXN1 deletions impaired neurotransmitter release in human neurons, suggesting a synaptic pathophysiol... View More