SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.

YJ, Hou; S, Chiba; P, Halfmann; C, Ehre; M, Kuroda; KH 3rd, Dinnon; SR, Leist; A, Schäfer; N, Nakajima; K, Takahashi; RE, Lee; TM, Mascenik; R, Graham; CE, Edwards; LV, Tse; K, Okuda; AJ, Markmann; L, Bartelt; Silva A, de; DM, Margolis; RC, Boucher; SH, Randell; T, Suzuki; LE, Gralinski; Y, Kawaoka; RS, Baric

doi:10.1126/science.abe8499

Public

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.

Shared by NobleBlocks on Nov 12, 2020 • 12:00 AM UTC

Authors:

Hou YJ

Chiba S

Halfmann P

Abstract

The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. The var...

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