Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

X, Yin; K, Kim; H, Suetsugu; SY, Bang; L, Wen; M, Koido; E, Ha; L, Liu; Y, Sakamoto; S, Jo; RX, Leng; N, Otomo; V, Laurynenka; YC, Kwon; Y, Sheng; N, Sugano; N, Sugano; MY, Hwang; W, Li; M, Mukai; K, Yoon; M, Cai; K, Ishigaki; WT, Chung; H, Huang; D, Takahashi; SS, Lee; M, Wang; K, Karino; SC, Shim; X, Zheng; T, Miyamura; YM, Kang; D, Ye; J, Nakamura; CH, Suh; Y, Tang; G, Motomura; YB, Park; H, Ding; T, Kuroda; JY, Choe; C, Li; H, Niiro; Y, Park; C, Shen; T, Miyamoto; GY, Ahn; W, Fei; T, Takeuchi; JM, Shin; K, Li; Y, Kawaguchi; YK, Lee; Y, Wang; K, Amano; DJ, Park; W, Yang; Y, Tada; K, Yamaji; M, Shimizu; T, Atsumi; A, Suzuki; T, Sumida; Y, Okada; K, Matsuda; K, Matsuo; Y, Kochi; LC, Kottyan; MT, Weirauch; S, Parameswaran; S, Eswar; H, Salim; X, Chen; K, Yamamoto; JB, Harley; K, Ohmura; TH, Kim; S, Yang; T, Yamamoto; BJ, Kim; N, Shen; S, Ikegawa; HS, Lee; X, Zhang; C, Terao; Y, Cui; SC, Bae

doi:10.1136/annrheumdis-2020-219209

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Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.

Shared by NobleBlocks on Dec 3, 2020 • 12:00 AM UTC

Authors:

Yin X

Kim K

Suetsugu H

Abstract

<h4>Objective</h4>Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disea...

Subject

Polymorphism

Genetic

Lupus erythematosus

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