METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.

Z, Xu; K, Jia; H, Wang; F, Gao; S, Zhao; F, Li; J, Hao

doi:10.1038/s41419-020-03312-0

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METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.

Shared by NobleBlocks on Jan 4, 2021 • 12:00 AM UTC

Authors:

Xu Z

Jia K

Wang H

Abstract

Histone deacetylase 5 (HDAC5) belongs to class II HDAC subfamily and is reported to be increased in the kidneys of diabetic patients and animals. However, little is known about its function and the exact mechanism in diabetic kidney disease (DKD). Here, we found that HDAC5 was located in renal glome...

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