Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

PH, Nguyen; A, Ramamoorthy; BR, Sahoo; J, Zheng; P, Faller; JE, Straub; L, Dominguez; JE, Shea; NV, Dokholyan; Simone A, De; B, Ma; R, Nussinov; S, Najafi; ST, Ngo; A, Loquet; M, Chiricotto; P, Ganguly; J, McCarty; MS, Li; C, Hall; Y, Wang; Y, Miller; S, Melchionna; B, Habenstein; S, Timr; J, Chen; B, Hnath; B, Strodel; R, Kayed; S, Lesné; G, Wei; F, Sterpone; AJ, Doig; P, Derreumaux

doi:10.1021/acs.chemrev.0c01122

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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Shared by NobleBlocks on Feb 5, 2021 • 12:00 AM UTC

Authors:

Nguyen PH

Ramamoorthy A

Sahoo BR

Abstract

Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computat...

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