Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

CG, Hughes; PT, Mailloux; JW, Devlin; JT, Swan; RD, Sanders; A, Anzueto; JC, Jackson; AS, Hoskins; BT, Pun; OM, Orun; R, Raman; JL, Stollings; AL, Kiehl; MS, Duprey; LN, Bui; HR Jr, O'Neal; A, Snyder; MA, Gropper; KK, Guntupalli; GJ, Stashenko; MB, Patel; NE, Brummel; TD, Girard; RS, Dittus; GR, Bernard; EW, Ely; PP, Pandharipande

doi:10.1056/nejmoa2024922

Public

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

Shared by NobleBlocks on Feb 2, 2021 • 12:00 AM UTC

Authors:

Hughes CG

Mailloux PT

Devlin JW

Abstract

Background Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation. Whether they affect outcomes differentially in mechanically ventilat...

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