Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.

SY, Sun; XT, Hu; XF, Yu; YY, Zhang; XH, Liu; YH, Liu; SH, Wu; YY, Li; SX, Cui; XJ, Qu

doi:10.1111/bph.15422

Public

Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.

Shared by NobleBlocks on Apr 29, 2021 • 12:00 AM UTC

Authors:

Sun SY

Hu XT

Yu XF

Abstract

<h4>Background and purpose</h4>It is well known that microsatellite instability-high (MSI-H) is associated with 5-fluorouracil (5-FU) resistance in colorectal cancer. MSI-H is the phenotype of DNA mismatch repair deficiency (MMR-D), mainly occurring due to hypermethylation of MLH1 promoter CpG islan...

Subject

Colorectal Cancer

5-Fu Resistance

Mis18α

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