Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

PA, Brown; L, Ji; X, Xu; M, Devidas; LE, Hogan; MJ, Borowitz; EA, Raetz; G, Zugmaier; E, Sharon; MB, Bernhardt; SA, Terezakis; L, Gore; JA, Whitlock; MA, Pulsipher; SP, Hunger; ML, Loh

doi:10.1001/jama.2021.0669

Public

Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

Published in JAMA • Mar 1, 2021

Authors:

Brown PA

Ji L

Xu X

Abstract

<h4>Importance</h4>Standard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially for patients with early relapse (high risk) or late relap...

View

Open Access

Generate AI Take for this paper

Highlights, strengths & weaknesses, commercial applications, and societal impact — written for this paper on demand.

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!