Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

Z, Vinarov; M, Abdallah; JAG, Agundez; K, Allegaert; AW, Basit; M, Braeckmans; J, Ceulemans; M, Corsetti; BT, Griffin; M, Grimm; D, Keszthelyi; M, Koziolek; CM, Madla; C, Matthys; LE, McCoubrey; A, Mitra; C, Reppas; J, Stappaerts; N, Steenackers; NL, Trevaskis; T, Vanuytsel; M, Vertzoni; W, Weitschies; C, Wilson; P, Augustijns

doi:10.1016/j.ejps.2021.105812

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Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

Shared by NobleBlocks on Mar 20, 2021 • 12:00 AM UTC

Authors:

Vinarov Z

Abdallah M

Agundez JAG

Abstract

The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populations (age- and disease-dependent), drug and formul...

Subject

Physiology

Variation

Diseases

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